MovDisordV3, Main, Exploration, bibRecord, 002A46

Validation of the "QUICK" Questionnaire : A Tool for Diagnosis of "Wearing-Off" in Patients with Parkinson's Disease

Identifieur interne : 002A46 ( Main/Exploration ); précédent : 002A45; suivant : 002A47

Validation of the "QUICK" Questionnaire : A Tool for Diagnosis of "Wearing-Off" in Patients with Parkinson's Disease

Auteurs : Pablo Martinez-Martin [Espagne] ; Eduardo Tolosa [Espagne] ; Basilio Hernandez [Espagne] ; Xavier Badia [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0251872

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Validation, Questionnaire, Diagnostic, Homme, Dépistage, Validité.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Diagnosis, Human, Medical screening, Nervous system diseases, Parkinson disease, Questionnaire, Validation, Validity.

Abstract

: The main objective of the present study was to test the validity of a 19-items instrument (QUICK Questionnaire, QQ) as a tool for screening of WO. Two hundred twenty-two patients (36.0% without WO; 64.0% with mild or moderate/ severe WO) were included. Diagnosis of WO by the participant neurologist was considered the "gold standard." The complete Unified Parkinson's Disease Rating Scale battery, the Cumulative Illness Rating Scale-Geriatrics, and a form about WO presence and severity were completed by the neurologist. Patients independently completed the QQ just before the clinical assessment. As a whole, patients with WO were more disabled than patients without and patients with moderate/severe WO were in worse condition than patients with mild WO. The number of QQ symptoms declared to improve usually after the following dose of medication was 1.0 ± 1.8 in the group without WO, but 6.0 ± 3.8 in patients with WO (P < 0.001). A two QQ positive symptoms cut-off showed the following attributes: sensitivity, 88%; specificity, 80%; positive predictive value, 88.7%; negative predictive value, 79%; diagnostic accuracy, 85%; positive and negative likelihood ratios 4.4 and 0.15, respectively. The area under the ROC curve resulted 0.90 (CI95%: 0.86-0.94%). In summary, the QQ proved to be a valid screening tool to identify WO in PD patients. To our knowledge, the QQ is the only validated tool for diagnosis of WO.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">: The main objective of the present study was to test the validity of a 19-items instrument (QUICK Questionnaire, QQ) as a tool for screening of WO. Two hundred twenty-two patients (36.0% without WO; 64.0% with mild or moderate/ severe WO) were included. Diagnosis of WO by the participant neurologist was considered the "gold standard." The complete Unified Parkinson's Disease Rating Scale battery, the Cumulative Illness Rating Scale-Geriatrics, and a form about WO presence and severity were completed by the neurologist. Patients independently completed the QQ just before the clinical assessment. As a whole, patients with WO were more disabled than patients without and patients with moderate/severe WO were in worse condition than patients with mild WO. The number of QQ symptoms declared to improve usually after the following dose of medication was 1.0 ± 1.8 in the group without WO, but 6.0 ± 3.8 in patients with WO (P < 0.001). A two QQ positive symptoms cut-off showed the following attributes: sensitivity, 88%; specificity, 80%; positive predictive value, 88.7%; negative predictive value, 79%; diagnostic accuracy, 85%; positive and negative likelihood ratios 4.4 and 0.15, respectively. The area under the ROC curve resulted 0.90 (CI95%: 0.86-0.94%). In summary, the QQ proved to be a valid screening tool to identify WO in PD patients. To our knowledge, the QQ is the only validated tool for diagnosis of WO.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Validation of the "QUICK" Questionnaire : A Tool for Diagnosis of "Wearing-Off" in Patients with Parkinson's Disease

Validation of the "QUICK" Questionnaire : A Tool for Diagnosis of "Wearing-Off" in Patients with Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri